preparation | 4-methylthioethane is used as raw material, which is firstly chloromethylated to produce 4-methylthiochloroethane, magnesium is then added to form a Grignard reagent, hydrolyzed with carbon dioxide to give 4-methylthioacetic acid, and finally oxidized to 4-methanesulfonylacetic acid. In the synthetic route, the Grignard reagent reaction requires high requirements, and must be anhydrous and oxygen-free, and the experimental operation requirements are also high, thus increasing the difficulty of industrialization. In this paper, 1-chloro-2-(methylthio) ethane is used as raw material, and 4-methylthioacetic acid is obtained by hydrolysis after cyano nucleophilic substitution, and finally oxidized to methylsulfonyl acetic acid. Its synthetic route is shown in Figure 1. In the synthetic route, sodium hydride has serious toxic environmental pollution, more nucleophilic substitution by-products, and higher reaction operation requirements, which is not conducive to industrial production and environmental friendliness. |